Hypo-osmolar Hartmann's

Cytotoxicity of Hypo-osmolar Lavage Fluid on Ovarian Cancer Cells In vitro

Objective: Ovarian cancer is difficult to diagnose early and many patients present with advanced disease. The presence of exfoliated ovarian cancer cells in the peritoneal cavity after debulking surgery is a poor prognostic indicator. Sterilization of the peritoneum during surgery may have clinical benefit in reducing tumor burden. Several studies have evaluated osmotic cytotoxicity in gastroin...

Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.

Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized. In this study, we showed that hypo-osmolarity induces p75NTR expression in primary neurons, and, using a comparative genomics approach, we identified conserved elements in the 25 kb...

High altitude exposure reduces bronchial responsiveness to hypo-osmolar aerosol in lowland asthmatics.

It is well-known that many patients with asthma undergo clinical improvement during a stay at high altitude. At high altitude, the atmospheric and climatic conditions (such as hypoxia, cold and dry air inhalation) could modify the bronchial responsiveness in asthmatics. Our study was designed to assess the difference in bronchial responsiveness to hypotonic aerosol between sea level and high al...

Osmolar disorders.

OBJECTIVE To present a practical approach to the management of osmolar disorders by considering the mechanisms involved in their development. DATA SOURCES Articles and published peer-review abstracts on the mechanisms and management of disorders of plasma osmolality. SUMMARY OF REVIEW In health, plasma osmolality is determined largely by the concentration of sodium and its accompanying anio...

Pre-operative Carbamazepine-induced Hyponatraemia: Should We Accept a Reset Hypo-osmolar Baseline and Proceed with Surgery?